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Rheumatoid Arthritis
Rheumatoid arthritis is a chronic systemic inflammatory disease whose major manifestation is synovitis of multiple joints. It has a prevalence of 1% and is more
Crystal Deposition Arthritis
Gouty Arthritis Gout is a metabolic disease of a heterogeneous nature, often familial, associated with abnormal deposits of urate in tissues and characterized initially by
Degenerative Joint Disease (Osteoarthritis)
Osteoarthritis, the most common form of joint disease, is chiefly a disease of aging. Ninety percent of all people have radiographic features of osteoarthritis in
Rheumatologic Disorders (Diagnosis and Evaluation)
Diagnosis and Evaluation of Rheumatologic Disorders Physical Examination Two helpful clinical clues for diagnosing arthritis are the joint pattern and the presence or absence of
Primary Immunodeficiency Disorders (In Adults)
Primary immunologic deficiency diseases are estimated to affect 1 in 4000 individuals; most are genetically determined and present in early childhood. Nonetheless, several important immunodeficiency
Delayed Drug Hypersensitivity
Drug Exanthems The clinical manifestation of drug exanthems is vast, ranging from common morbilliform rashes to severe cutaneous adverse reactions (SCARs) (eg, Stevens-Johnson syndrome [SJS]/toxic
Adverse Drug Reactions
Drug Allergy (IgE-Mediated Immediate Hypersensitivity Reactions Prick skin testing for most low-molecular-weight drugs is not validated and is interpretable only if the test is positive
Immediate Hypersensitivity
Food Allergy Clinical Findings Immediate hypersensitivity IgE-mediated allergic reactions to foods commonly occur within 2 hours of ingestion and are much less common in adults
Inflammatory Bowel Disease-Associated Spondyloarthritis
One-fifth of patients with IBD have arthritis, which complicates Crohn disease somewhat more frequently than it does ulcerative colitis. In both diseases, two distinct forms
Reactive Arthritis
Reactive arthritis is precipitated by antecedent GI or genitourinary infections and manifests as an asymmetric sterile oligoarthritis, typically of the lower extremities. It is frequently
Psoriatic Arthritis
Although psoriasis usually precedes the onset of arthritis, arthritis may precede skin disease by up to 2 years or psoriasis and arthritis may occur simultaneously
Axial Spondyloarthritis (Ankylosing Spondylitis)
Axial spondyloarthritis (SpA) is a general term for arthritic conditions that affect the spine and sacroiliac joints. There are two types: radiographic, which shows changes