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Primary immunologic deficiency diseases are estimated to affect 1 in 4000 individuals; most are genetically determined and present in early childhood. Nonetheless, several important immunodeficiency disorders present in adulthood, most notably the antibody deficiency syndromes: selective IgA deficiency, common variable…
Drug Exanthems The clinical manifestation of drug exanthems is vast, ranging from common morbilliform rashes to severe cutaneous adverse reactions (SCARs) (eg, Stevens-Johnson syndrome [SJS]/toxic epidermal necrolysis [TEN], drug reaction with eosinophilia and systemic symptoms [DRESS], acute generalized exanthematous pustulosis…
Drug Allergy (IgE-Mediated Immediate Hypersensitivity Reactions Prick skin testing for most low-molecular-weight drugs is not validated and is interpretable only if the test is positive at a nonirritating concentration. Testing for IgE-mediated allergy to penicillin (PCN) is validated; skin testing…
Food Allergy Clinical Findings Immediate hypersensitivity IgE-mediated allergic reactions to foods commonly occur within 2 hours of ingestion and are much less common in adults as a de novo food allergy than in children. Typical reactions include a combination of…